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Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment.
Mental disorders pose a significant global burden and constitute a major cause of disability worldwide. Despite strides in treatment, a substantial number of patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promi…
The cognitive neuroscience of ketamine in major depression.
Ketamine's potential as a rapid-acting antidepressant was first identified in 2000, despite its long-standing use as an anesthetic agent. Clinically, ketamine alleviates depressive symptoms, including the difficult to treat symptom of anhedonia, within hours, with the effects of a single dose lasting for days. Since t…
Linking microscopy to diffusion MRI with degenerate biophysical models: an application of the Bayesian EstimatioN of CHange (BENCH) framework
Abstract Biophysical modelling of diffusion MRI (dMRI) is used to non-invasively estimate microstructural features of tissue, particularly in the brain. However, meaningful description of tissue requires many unknown parameters, resulting in a model that is often ill-posed. The Bayesian EstimatioN of CHange (BENC…
Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: a 7T magnetic resonance spectroscopy study.
Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a common debilitating medical condition, whose main symptoms - fatigue, post-exertional malaise and cognitive dysfunction - are also present in many cases of long COVID. Magnetic resonance spectroscopy (MRS) allows the insight into their pathophysiol…
Multi-site feasibility and reproducibility study on UTE 3D phosphorous MRSI using novel rosette trajectory (PETALUTE).
PURPOSE: This study aims (1) to implement a robust acquisition, fully automated reconstruction, and processing pipeline using a novel rosette k-space pattern for UTE 31P 3D MRSI and (2) to evaluate the clinical applicability and reproducibility at different experimental setups. METHODS: A multi-center feas…
The Effects of Theta-Gamma Peak Stimulation on Sensorimotor Learning during Speech Production
Abstract Transcranial alternating current stimulation (tACS) is a non-invasive neuromodulatory tool that is thought to entrain intrinsic neural oscillations by supplying low electric currents over the scalp. Recent work has demonstrated the efficacy of theta-gamma phase-amplitude coupled tACS over primary mo…
Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data
Anatomic tracing is the gold standard tool for delineating brain connections and for validating more recently developed imaging approaches such as diffusion MRI tractography. A key step in the analysis of data from tracer experiments is the careful, manual charting of fiber trajectories on histological sections. Thi…
The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank study.
The number of people living with dementia worldwide is projected to reach 150 million by 2050, making prevention a crucial priority for health services. The co-occurrence of two or more chronic health conditions, termed multimorbidity, occurs in up to 80% of dementia patients, making multimorbidity an import…
Cryoneurolysis: A Novel Treatment for Management of Spasticity. Presentation of a Case Series
Background: Spasticity is a motor phenomenon occurring in disorders of the central nervous system that impacts on active and passive function, and quality of life. Pharmacological, physical and surgical management options are available, each of which have limitations. Cryoneurolysis is a technique developed f…
Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial.
BACKGROUND: Lithium and several atypical antipsychotics are the recommended first-line augmentation options for treatment-resistant depression; however, few studies have compared them directly, and none for longer than 8 weeks. Consequently, there is little evidence-based guidance for clinicians…
Negative bias in encoding and recall memory in depressed patients with inadequate response to antidepressant medication.
RATIONALE: Cognitive theories propose that negative biases in emotional processing contribute to the maintenance of depressive states. Previous studies reported that acute antidepressant treatment in depressed patients reversed negative emotional biases. However, studies addressing the differences in em…
Using arterial spin labelling to investigate spontaneous and evoked ongoing musculoskeletal pain
Clinical pain is difficult to study using standard Blood Oxy-genation Level Dependent (BOLD) magnetic resonance imaging because it is often ongoing and, if evoked, it is associated with stimulus-correlated motion. Arterial spin labelling (ASL) offers an attractive alternative. This study used arm repositioning to ev…
Evaluating functional brain organization in individuals and identifying contributions to network overlap.
Individual differences in the spatial organization of resting-state networks have received increased attention in recent years. Measures of individual-specific spatial organization of brain networks and overlapping network organization have been linked to important behavioral and clinical traits and are therefore p…
Longer scans boost prediction and cut costs in brain-wide association studies.
A pervasive dilemma in brain-wide association studies1 (BWAS) is whether to prioritize functional magnetic resonance imaging (fMRI) scan time or sample size. We derive a theoretical model showing that individual-level phenotypic prediction accuracy increases with sample size and total scan duration (sample…
An fMRI study of initiation and inhibition of manual and spoken responses in people who stutter
Abstract Stuttering is characterised by difficulties initiating speech and frequent interruptions to the flow of speech. Neuroimaging studies of speech production in people who stutter consistently reveal greater activity of the right inferior frontal cortex, an area robustly implicated in stopping manual and s…
Corrigendum to “Relating TMS measures of GABAergic and Cholinergic signalling to attention” [Brain Stimul 18 (1) (2025) 507–508, (S1935861X24010489), (10.1016/j.brs.2024.12.853)]
The authors regret that some of the authors are omitted in the original publication. The correct list of authors is as presented above. The authors also regret the errors in the abstract text. The corresponding corrections are provided below: The first line of paragraph 3 of the abstract should read: Here we investi…